Яндекс Маркет

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Яндекс Яндекс

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Игорь Горький

5 отзывов

1 ответ

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Инспектор гаджетов 5 уровня

Электроника

Айтишник 5 уровня

Компьютерная техника

Все уровни

5 достижений

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(МАО).\u003Cbr\u003EНепереносимость лактозы, дефицит лактазы или глюкозо-галактозная мальабсорбция (в связи с наличием в составе лактозы).\u003Cbr\u003EПрименение препарата Каликста для лечения детей до 18 лет не рекомендуется, поскольку эффективность миртазапина не была продемонстрирована в двух краткосрочных клинических исследованиях, а также на основании данных по безопасности."},{"description":"","filters":[{"id":15768292,"name":"Состав"}],"isMainProperty":false,"name":"Состав","value":"Одна таблетка, покрытая пленочной оболочкой содержит:\u003Cbr\u003Eдействующее вещество: миртазапин 15,0 / 30,0 / 45,0 мг.\u003Cbr\u003EВспомогательные вещества: лактозы моногидрат - 44,40 / 88,80 / 133,20 мг, крахмал кукурузный - 28,00 / 56,00 / 84,00 мг, гипролоза - 15,00 / 30,00 / 45,00 мг, целлюлоза микрокристаллическая - 15,00 / 30,00 / 45,00 мг, крахмал прежелатинизированный - 15,00 / 30,00 / 45,00 мг, тальк - 1,40 / 2,80 / 4,20 мг, магния стеарат - 0,70 / 1,40/ 2,10 мг, кремния диоксид коллоидный - 0,50 / 1,00 / 1,50 мг;\u003Cbr\u003Eоболочка таблетки: гипромеллоза-5 CPS - 2,40 / 4,80 / 7,20 мг, макрогол 6000 - 0,20 / 0,40 / 0,60 мг, титана диоксид - 0,25 / 0,50 / 1,05 мг, тальк - 0,05 / 0,10 / 0,15 мг, краситель железа оксид желтый (Е 172) (для дозировок 15 мг и 30 мг) - 0,10/0,15 мг, краситель железа оксид красный (Е 172) (для дозировки 30 мг) - 0,05 мг."},{"description":"","filters":[{"id":27144131,"name":"Действующее вещество"}],"isMainProperty":false,"name":"Действующее вещество","value":"Миртазапин"},{"description":"","filters":[{"id":15768000,"name":"Способ применения и дозы"}],"isMainProperty":false,"name":"Способ применения и дозы","value":"Внутрь, не разжевывая, запивая небольшим количеством жидкости.\u003Cbr\u003EВзрослые:\u003Cbr\u003EЭффективная суточная доза обычно составляет от 15 мг до 45 мг; начальная доза составляет 15 мг или 30 мг.\u003Cbr\u003EПожилые пациенты:\u003Cbr\u003EРекомендуемая доза аналогична таковой для взрослых пациентов. Для достижения удовлетворительного эффекта и обеспечения безопасности увеличение дозы пожилым пациентам следует проводить под непосредственным наблюдением врача.\u003Cbr\u003EПациенты с нарушением функции почек\u003Cbr\u003EКлиренс миртазапина может быть снижен у пациентов с умеренным или тяжелым нарушением функции почек (клиренс креатинина (КК) \u003C 40 мл/мин). Это следует учитывать при назначении препарата Каликста этой группе пациентов.\u003Cbr\u003EПациенты с нарушением функции печени\u003Cbr\u003EКлиренс миртазапина может быть снижен у пациентов с нарушением функции печени. Это следует учитывать при назначении препарата Каликста этой группе пациентов, особенно при тяжелом нарушении функции печени, так как применение миртазапина у данной группы пациентов не изучалось.\u003Cbr\u003EПрепарат Каликста можно принимать 1 раз в сутки, предпочтительнее в одно и то же время, перед сном. Можно принимать 2 раза в сутки, поделив суточную дозу на два приема (один раз утром и один раз на ночь, более высокую дозу следует принимать на ночь).\u003Cbr\u003EЛечение следует по возможности продолжать в течение 4-6 месяцев до полного исчезновения симптомов. После этого лечение можно постепенно отменять.\u003Cbr\u003EМиртазапин начинает оказывать свое действие обычно через 1-2 недели лечения.\u003Cbr\u003EЛечение адекватной дозой должно привести к положительному результату в течение 2-4 недель. При недостаточном клиническом ответе на лечение доза может быть увеличена до максимальной дозы (до 45 мг). При отсутствии ответа на лечение в течение дополнительных 2-4 недель лечение следует прекратить."},{"description":"","filters":[{"id":15767998,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"У пациентов с депрессией наблюдается ряд симптомов, обусловленных заболеванием, поэтому иногда бывает трудно различить симптомы самого заболевания, и симптомы, вызванные применением препарата.\u003Cbr\u003EНаиболее частыми нежелательным реакциям, которые наблюдались более чем у 5% пациентов, получавших миртазапин в рамках рандомизированных плацебо-контролируемых исследований, были сонливость, седативный эффект, сухость во рту, увеличение массы тела, повышение аппетита, головокружение и усталость.\u003Cbr\u003EВо всех рандомизированных плацебо-контролируемых исследованиях у пациентов была проведена оценка нежелательных реакций на миртазапин (включая как применение по показанию \"глубокое депрессивное расстройство\", так и по прочим показаниям). Мета-анализ охватывал 20 исследований с запланированной продолжительностью лечения до 12 недель, включавших 1501 пациента (134 пациенто-лет), получавших дозы миртазапина до 60 мг, и 850 пациентов (79 пациенто-лет), получавших плацебо. Продленные фазы этих исследований были исключены из анализа для сохранения сопоставимости данных с плацебо.\u003Cbr\u003EНиже представлена частота нежелательных реакций по категориям, которые наблюдались в клинических исследованиях статистически значимо чаще во время лечения миртазапином по сравнению с плацебо, с добавлением нежелательных реакций, отмеченных в спонтанных сообщениях. Указанная частота нежелательных реакций по данным спонтанных сообщений во время применения препарата в реальной клинической практике основана на частоте случаев этих нежелательных реакций согласно клиническим исследованиям.\u003Cbr\u003EЧастота нежелательных реакций, отмеченных в спонтанных сообщениях, по которым не отмечено ни одного случая в рандомизированных плацебо-контролируемых исследованиях у пациентов, получавших миртазапин, классифицирована как \"частота неизвестна\". Для обозначения частоты побочных эффектов используется следующая классификация: очень часто (≥1/10), часто (≥1/100 и \u003C1/10), нечасто (≥1/1000 и \u003C1/100), редко (≥1/10000 и \u003C1/1000), частота не установлена (\u003C1/10000)\u003Cbr\u003EСо стороны крови и лимфатической системы: частота неизвестна - угнетение функции костного мозга (гранулоцитопения, агранулоцитоз, апластическая анемия, тромбоцитопения), эозинофилия.\u003Cbr\u003EНарушения со стороны эндокринной системы: частота неизвестна - синдром неадекватной секреции антидиуретичсского гормона.\u003Cbr\u003EНарушения со стороны обмена веществ и питания: очень часто - увеличение массы тела1, повышенный аппетит1; частота неизвестна - гипонатриемия.\u003Cbr\u003EНарушения психики: часто - необычные сны, спутанность сознания, тревога2,5, бессонница3,5; нечасто - ночные кошмары2, мания, ажитация2, галлюцинации, психомоторное возбуждение (в том числе акатизия, гиперкинезия); редко - агрессивность; частота неизвестна - суицидальные мысли6, суицидальное поведение6.\u003Cbr\u003EНарушения со стороны нервной системы: очень часто - сонливость1,4, седация1,4, головная боль2; часто - заторможенность1, головокружение, тремор; нечасто - парестезия2, синдром \"беспокойных ног\", обморок; редко - миоклонус; частота неизвестна - судороги, серотониновый синдром, парестезии слизистой оболочки полости рта, дизартрия.\u003Cbr\u003EНарушения со стороны сердечно-сосудистой системы: часто - ортостатическая гипотензия; нечасто - снижение артериального давления2.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта: очень часто - сухость во рту; часто - тошнота3, диарея2, рвота2, запор1; нечасто - гипестезия слизистой оболочки полости рта; редко - панкреатит; частота неизвестна - отек слизистой оболочки полости рта, повышенное слюноотделение.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей: редко - повышение активности трансаминаз сыворотки.\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей: часто - кожная сыпь2; частота неизвестна - синдром Стивенса-Джонсона, буллезный дерматит, мультиформная эритема, токсический эпидермальный некролиз.\u003Cbr\u003EНарушения со стороны скелетно-мышечной системы и соединительной ткани: часто - артралгия, миалгия, боль в спине1; частота неизвестна - рабдомиолиз7.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей: частота неизвестна - задержка мочи.\u003Cbr\u003EОбщие расстройства и нарушения в месте введения: часто - периферические отеки1, утомляемость; частота неизвестна - сомнамбулизм, генерализованный отек, локализованный отек.\u003Cbr\u003EЛабораторные и инструментальные данные: частота неизвестна - увеличение активности креатинкиназы.\u003Cbr\u003E1 В ходе клинических исследований данные явления отмечались статистически достоверно чаще на фоне терапии миртазапином, чем при применении плацебо.\u003Cbr\u003E2 В ходе клинических исследований данные явления отмечались чаще при применении плацебо, чем на фоне терапии миртазапином, однако разница не была статистически достоверной.\u003Cbr\u003E3 В ходе клинических исследований данные явления отмечались статистически достоверно чаще при применении плацебо, чем на фоне терапии миртазапином.\u003Cbr\u003E4 Снижение дозы, как правило, не приводит к уменьшению сонливости и/или избыточного седативного действия, однако может привести к снижениюэффективности антидепрессанта.\u003Cbr\u003E5 При лечении антидепрессантами могут появиться или усиливаться тревога и бессонница (которые также могут быть симптомами депрессии). На фоне терапии миртазапином были отмечены случаи возникновения или усиления тревоги и бессонницы.\u003Cbr\u003E6 Были зарегистрированы случаи суицидальных намерений и суицидального поведения на фоне терапии миртазапином или вскоре после прекращения терапии.\u003Cbr\u003EО случаях рабдомиолиза сообщалось в связи с серотониновым синдромом и передозировкой несколькими препаратами. В последнем случае причинно-следственная связь с приемом миртазапина не была установлена.\u003Cbr\u003EПри оценке данных, полученных в ходе клинических исследований, наблюдалось временное повышение активности трансаминаз и гамма-глутамилтранспептидазы (однако не сообщалось о каких-либо побочных реакциях, связанных с приемом миртазапина, которые возникали с большей частотой, чем при применении плацебо)."},{"description":"","filters":[{"id":15768001,"name":"Фармакологическое действие"}],"isMainProperty":false,"name":"Фармакологическое действие","value":"Фармакологические свойства\u003Cbr\u003EПрепарат Каликста является тетрациклическим антидепрессантом с преимущественно седативным действием.\u003Cbr\u003EПрепарат эффективен при депрессивных состояниях с наличием в клинической картине таких симптомов, как неспособность испытывать удовольствие и радость, потеря интереса (ангедония), психомоторная заторможенность, нарушения сна (особенно в виде ранних пробуждений) и потеря веса, а также других симптомов: суицидальных мыслей и суточных колебаний настроения.\u003Cbr\u003EАнтидепрессивный эффект препарата Каликста обычно наступает через 1-2 недели лечения.\u003Cbr\u003EФармакодинамика\u003Cbr\u003EМиртазапин является антагонистом пресинаптических аг-адренорецепторов в центральной нервной системе и усиливает центральную норадренергическую и серотонинергическую передачу нервных импульсов. При этом усиление серотонинергической передачи реализуется только через серотониновые 5-HT1-рецепторы, поскольку миртазапин блокирует серотониновые 5-НТ2 и 5-НТ3-рецепторы. Считается, что оба энантиомера миртазапина обладают антидепрессивной активностью, S(+) энантиомер - блокируя α2-адрено- и серотониновые 5-НТ2-рецепторы, a R(-) энантиомер - блокируя серотониновые 5-НТ3-рецепторы.\u003Cbr\u003EСедативные свойства миртазапина обусловлены его антагонистической активностью по отношению к H1-гистаминовым рецепторам.\u003Cbr\u003EМиртазапин обычно хорошо переносится, практически не обладает м-холинблокирующей активностью и в терапевтических дозах оказывает ограниченный эффект (например, ортостатическая гипотензия) на сердечно-сосудистую систему.\u003Cbr\u003EДети\u003Cbr\u003EБыли проведены два рандомизированных двойных слепых плацебо-контролируемых исследования у детей в возрасте от 7 до 18 лет с глубоким депрессивным расстройством (n=259), в течение первых 4 недель получавших миртазапин по гибкой схеме дозирования (15-45 мг) и в течение последующих 4 недель получавших фиксированные дозы (15, 30 или 45 мг) миртазапина.\u003Cbr\u003EДанные исследований не продемонстрировали значительных различий между миртазапином и плацебо. В ходе исследований у 48,8% пациентов, получавших миртазапин, наблюдалось значительное (более 7%) увеличение массы тела по сравнению с группой плацебо (5,7%). Также часто наблюдались крапивница (11,8% у пациентов, получавших миртазапин, и 6,8% у пациентов, получавших плацебо) и гипертриглицеридемия (2,9% у пациентов, получавших миртазапин, и 0 % у пациентов, получавших плацебо)."},{"description":"","filters":[{"id":34045110,"name":"Фармакологическая группа"}],"isMainProperty":false,"name":"Фармакологическая группа","value":"антидепрессанты"},{"description":"","filters":[{"id":27141511,"name":"Форма выпуска для карточки"}],"isMainProperty":false,"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"description":"","filters":[{"id":35947170,"name":"Способ применения/введения"}],"isMainProperty":false,"name":"Способ применения/введения","value":"пероральный"},{"description":"","filters":[{"id":23679511,"name":"Минимальный возраст применения"},{"id":16082123,"name":"С рождения"}],"isMainProperty":false,"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","specs":[{"description":"","filters":[{"id":15767999,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"Хранить при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"description":"","filters":[{"id":15768014,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"Имеющийся опыт наблюдения случаев передозировки только миртазапином указывает на то, что симптомы обычно слабо выражены. Сообщалось об угнетении центральной нервной системы, сопровождавшемся дезориентацией и продолжительным седативным эффектом в сочетании с тахикардией и незначительным повышением или понижением артериального давления. Однако при приеме доз, значительно превышающих терапевтическую дозу, особенно при передозировках несколькими препаратами, принятыми одновременно, существует вероятность более серьезных последствий (включая летальный исход). В таких случаях также сообщалось об удлинении интервала QT и тахикардии по типу \"пируэт\".\u003Cbr\u003EВ случае передозировки необходимо проводить соответствующее симптоматическое лечение для поддержания жизненно важных функций организма, а также мониторинг ЭКГ (электрокардиограммы). Следует ввести активированный уголь или выполнить промывание желудка."},{"description":"","filters":[{"id":15768015,"name":"Применение при беременности и кормлении грудью"}],"isMainProperty":false,"name":"Применение при беременности и кормлении грудью","value":"Имеющиеся ограниченные данные указывают на то, что при применении миртазапина у беременных женщин не было выявлено повышенного риска врожденных пороков развития плода. В ходе исследований у животных не было выявлено клинически значимого тератогенного действия, однако отмечалось токсическое влияние на плод.\u003Cbr\u003EПо эпидемиологическим данным применение ингибиторов обратного захвата серотонина при беременности, особенно на поздних сроках, может повысить риск развития персистирующей легочной гипертензии новорожденных (ПЛГН). Несмотря на отсутствие данных клинических испытаний, подтверждающих взаимосвязь между применением миртазапина и развитием ПЛГН, потенциальный риск нельзя исключать, принимая во внимание механизм действия миртазапина (повышение концентрации серотонина).\u003Cbr\u003EИсследования на животных и ограниченные данные исследований в отношении человека показали выделение миртазапина в грудное молоко только в очень небольших количествах. Пользу применения препарата для матери во время кормления грудью следует оценивать относительно возможных рисков для ребенка.\u003Cbr\u003EФертильность\u003Cbr\u003EИсследования репродуктивной токсичности на животных не продемонстрировали какого-либо влияния на фертильность."},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"Препарат Каликста может снижать концентрацию внимания. В период лечения пациентам следует избегать управления транспортными средствами и механизмами и выполнения потенциально опасных видов деятельности, требующих высокой скорости психомоторных реакций."},{"description":"","filters":[{"id":15771167,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"Пациенты детского возраста\u003Cbr\u003EПрепарат Каликста не следует применять у детей и подростков младше 18 лет.\u003Cbr\u003EСуицидальные проявления (попытки самоубийства и суицидальные мысли) и враждебность (преимущественно агрессия, оппозиционное поведение и гнев) в ходе клинических исследований наблюдались значительно чаще в группе детей и подростков, принимавших антидепрессанты, по сравнению с группой пациентов того же возраста, принимавших плацебо.\u003Cbr\u003EЕсли, исходя из клинической необходимости, все-таки принимается решение о применении препарата, следует тщательно контролировать появление суицидальных симптомов у пациентов.\u003Cbr\u003EКроме того, отсутствуют данные долгосрочных исследований безопасности относительно роста, созревания, а также когнитивного и поведенческого развития у детей и подростков.\u003Cbr\u003EСуицид/суицидальные мысли или клиническое ухудшение течения заболевания\u003Cbr\u003EЛюбое депрессивное расстройство само по себе увеличивает риск суицидальных мыслей и суицидального поведения. Этот риск сохраняется до наступления стойкой ремиссии заболевания. Поскольку улучшение может не наступить в течение первых нескольких недель терапии или более, состояния пациентов должно тщательно контролироваться до наступления улучшения. Клинический опыт показывает, что риск попыток суицида может увеличиваться на ранних стадиях выздоровления.\u003Cbr\u003EПациенты с суицидальным поведением в анамнезе, а также пациенты, у которых до начала терапии отмечались выраженные суицидальные намерения, относятся к группе повышенного риска появления суицидальных мыслей или попыток суицида и должны находиться под пристальным наблюдением.\u003Cbr\u003EМета-анализ результатов плацебо-контролируемых клинических исследований по применению антидепрессантов у взрослых пациентов с психическими расстройствами выявил повышенный риск суицидального поведения у пациентов, получавших антидепрессанты, по сравнению с группой плацебо, у пациентов в возрасте до 25 лет.\u003Cbr\u003EПациенты, получающие терапию антидепрессантами, особенно пациенты из группы повышенного риска, должны находиться под пристальным наблюдением, особенно на ранних этапах лечения и в случае корректировки дозы.\u003Cbr\u003EПациенты, а также лица, осуществляющие уход за ними, должны быть предупреждены о необходимости своевременного выявления любых признаков клинического ухудшения, суицидального поведения, суицидальных мыслей или необычного поведения, а также о необходимости незамедлительно сообщать врачу о появлении данных симптомов.\u003Cbr\u003EС учетом возможности суицида, особенно в начале терапии, пациенту следует назначить наименьшее количество таблеток препарата для снижения риска передозировки.\u003Cbr\u003EУгнетение функции костного мозга\u003Cbr\u003EПри применении миртазапина были зафиксированы случаи угнетения функций костного мозга, обычно проявляющиеся в виде гранулоцитопении или агранулоцитоза.\u003Cbr\u003EВ ходе клинических исследований в редких случаях отмечался обратимый агранулоцитоз. В ходе пострегистрационного наблюдения случаи агранулоцитоза регистрировались в очень редких случаях, в большинстве случаев он также был обратимым, однако было отмечено несколько летальных исходов, которые регистрировались в основном у пациентов старше 65 лет. Врачу следует внимательно отнестись к таким симптомам, как повышение температуры тела, боли в горле, стоматит и другим признакам гриппоподобного синдрома, и проинформировать об этом пациента; при возникновении подобных симптомов следует прекратить лечение и сделать анализ крови.\u003Cbr\u003EЖелтуха\u003Cbr\u003EПри появлении признаков желтухи лечение следует прекратить.\u003Cbr\u003EСостояния, требующие наблюдения врача\u003Cbr\u003EПрепарат следует назначать с осторожностью, а также осуществлять постоянное и тщательное наблюдение за пациентами при следующих состояниях/заболеваниях:\u003Cbr\u003E- Эпилепсия и органические поражения головного мозга. Несмотря на то, что клинический опыт показывает, что эпилептические приступы редко возникают при приеме как миртазапина, так и других антидепрессантов, препарат Каликста необходимо применять с осторожностью пациентам с эпилептическими приступами в анамнезе. Следует прекратить лечение при появлении или повышении частоты эпилептических приступов.\u003Cbr\u003E- Печеночная недостаточность. После однократного приема внутрь миртазапина в дозе 15 мг клиренс миртазапина уменьшался приблизительно на 35% у пациентов с печеночной недостаточностью легкой или средней степени тяжести по сравнению с пациентами с нормальной функцией печени. Средняя концентрация миртазапина в плазме крови увеличивалась приблизительно на 55%.\u003Cbr\u003E- Почечная недостаточность. После однократного приема внутрь миртазапина в дозе 15 мг у пациентов с почечной недостаточности средней (КК 10-40 мл/мин) или тяжелой (КК менее 10 мл/мин) степени клиренс миртазапина уменьшался приблизительно на 30 % и 50 % соответственно, по сравнению со здоровыми добровольцами. Средняя концентрация миртазапина в плазме крови увеличивалась приблизительно на 55 % и 115 % соответственно. У пациентов с почечной недостаточностью легкой степени тяжести (КК 40-80 мл/мин) значительных отличий по сравнению с контрольной группой не наблюдалось.\u003Cbr\u003E- Заболевания сердца, такие как нарушение проводимости, стенокардия и недавно перенесенный инфаркт миокарда. В данных случаях необходимы обычные меры предосторожности при назначении препарата Каликста и сопутствующей терапии.\u003Cbr\u003E- Низкое артериальное давление.\u003Cbr\u003E- Сахарный диабет. У пациентов с сахарным диабетом антидепрессанты могут влиять на содержание глюкозы в крови. Может потребоваться корректировка дозы инсулина и/или пероральных гипогликемических препаратов. Рекомендуется тщательное наблюдение.\u003Cbr\u003EКак и при применении других антидепрессантов, при применении препарата Каликста могут иметь место следующие состояния:\u003Cbr\u003E- Возможно ухудшение психотических симптомов при применении антидепрессантов для лечения пациентов с шизофренией или другими психотическими нарушениями, могут усилиться параноидальные идеи.\u003Cbr\u003E- Депрессивная фаза биполярного расстройства на фоне лечения может трансформироваться в маниакальную фазу. Пациенты с манией/олигоманией в анамнезе требуют тщательного наблюдения. Препарат следует отменить при наступлении у пациента маниакальной фазы.\u003Cbr\u003E- Несмотря на то, что препарат Каликста не вызывает привыкания, пострегистрационный опыт применения показывает, что резкое прекращение лечения после продолжительного применения может иногда стать причиной появления симптомов отмены. Большинство симптомов отмены являются слабыми и могут купироваться самостоятельно. Наиболее часто сообщалось о следующих симптомах отмены: головокружение, ажитация, тревога, головная боль и тошнота. Хотя о них сообщалось как о симптомах отмены, следует учитывать, что эти симптомы могут быть связаны с основным заболеванием. Лечение миртазапином рекомендуется прекращать постепенно.\u003Cbr\u003E-Препарат Каликста необходимо с осторожностью назначать пациентам с нарушениями мочеиспускания, в том числе, при гиперплазии предстательной железы, и пациентам с острой закрытоугольной глаукомой и повышенным внутриглазным давлением (однако негативное влияние миртазапина маловероятно в связи с его очень низкой антихолинергической активностью).\u003Cbr\u003E- Акатизия/психомоторное возбуждение: применение антидепрессантов связано с развитием акатизии, характеризующейся субъективно неприятным или тревожным беспокойством и необходимостью двигаться, зачастую сопровождающейся неспособностью сидеть или стоять на месте. Чаще всего это состояние проявляется в первые недели лечения. У пациентов с подобными симптомами увеличение дозы препарата может оказать негативное воздействие.\u003Cbr\u003E- Влияние миртазапина на интервал QTc оценивали в рандомизированном, плацебо и моксифлоксацин контролируемом клиническом исследовании, включавшем 54 здоровых добровольца, посредством анализа по типу экспозиция-ответ. Это исследование показало, что дозы миртазапина 45 мг (терапевтическая) и 75 мг (превышающая терапевтическую) не оказывали влияния на клинически значимое удлинение интервала QTc. В ходе пострегистрационного применения миртазапина были зарегистрированы случаи удлинения интервала QT на ЭКГ, желудочковой тахикардии (в том числе, тахикардии по типу \"пируэт\") и внезапной смерти. Однако в большинстве случаев эти симптомы отмечались на фоне передозировки или у пациентов с другими факторами риска удлинения интервала QTc, включая одновременный прием двух или нескольких лекарственных препаратов, вызывающих удлинение интервала QT. Необходимо соблюдать осторожность при назначении препарата Каликста пациентам с сердечно-сосудистыми заболеваниями, а также при наличии в семейном анамнезе удлиненного интервала QT или при сопутствующей терапии другими препаратами, которые могут вызывать удлинение интервала QTc.\u003Cbr\u003EГипонатриемия\u003Cbr\u003EПри применении миртазапина описаны крайне редкие случаи гипонатриемии.\u003Cbr\u003EПациентам из группы риска (пожилым пациентам или пациентам, принимающим препараты, которые могут вызывать гипонатриемию), препарат Каликста следует назначать с осторожностью.\u003Cbr\u003EСеротониновы и синдром\u003Cbr\u003EПри одновременном применении селективных ингибиторов обратного захвата серотонина и других серотонинергических препаратов может возникнуть серотониновый синдром.\u003Cbr\u003EСимптомами серотонинового синдрома могут быть лихорадка, ригидность, миоклонус, расстройство вегетативной нервной системы с возможными быстрыми колебаниями жизненно важных показателей функционального состояния организма, изменение психического состояния, включая спутанность сознания, раздражительность и сильное возбуждение, прогрессирующее в расстройство сознания и кому.\u003Cbr\u003EСледует соблюдать осторожность и осуществлять тщательное наблюдение при одновременном приеме этих препаратов с миртазапином. При возникновении подобных симптомов следует прекратить лечение препаратом Каликста и начать симптоматическое лечение.\u003Cbr\u003EПострегистрационный опыт показывает, что у пациентов, которые получают монотерапию миртазапином, серотониновый синдром возникает очень редко.\u003Cbr\u003EПожилые пациенты\u003Cbr\u003EПациенты пожилого возраста обычно более чувствительны к терапии, особенно в отношении побочных эффектов антидепрессантов. В ходе клинических исследований миртазапина было отмечено, что частота выявления нежелательных реакций у пациентов пожилого возраста не отличалась от показателей в других возрастных группах.\u003Cbr\u003EЛактоза\u003Cbr\u003EПрепарат Каликста содержит лактозы моногидрат, поэтому его не следует применять пациентам с непереносимостью лактозы, дефицитом лактазы, синдромом глюкозо- галактозной мальабсорбции.\u003Cbr\u003EПациентам следует избегать употребления алкоголя во время лечения препаратом Каликста.\u003Cbr\u003EСледует с осторожностью назначать препарат Каликста беременным женщинам. Если препарат Каликста применялся непосредственно перед родами или незадолго до родов, то в послеродовом периоде следует осуществлять тщательный контроль состояния новорожденного на предмет возможных проявлений синдрома отмены."},{"description":"","filters":[{"id":15768012,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"Фармакодинамическое взаимодействие\u003Cbr\u003EМиртазапин не следует применять в сочетании с ингибиторами МАО и в течение двух недель после прекращения лечения ингибитором МАО. Лечение ингибиторами МАО следует начинать не ранее, чем через две недели после прекращения лечения миртазапином.\u003Cbr\u003EОдновременный прием с другими серотонинергическими препаратами (L-триптофаном, триптанами, трамадолом, линезолидом, метиленовым синим, селективными ингибиторами обратного захвата серотонина, венлафаксином, препаратами лития и препаратами зверобоя продырявленного (Hypericum perforatum)) может привести к развитию серотонинового синдрома.\u003Cbr\u003EМиртазапин может усиливать седативные свойства бензодиазепинов и других седативных средств (в частности, большинства антипсихотических средств, антагонистов H1-гистаминовых рецепторов, опиоидов).\u003Cbr\u003EСледует проявлять осторожность при назначении вышеуказанных лекарственных средств вместе с миртазапином и проводить более тщательный клинический мониторинг.\u003Cbr\u003EМиртазапин может усиливать депрессивное действие алкоголя на ЦНС, поэтому пациенты должны быть предупреждены о необходимости избегать употребления спиртных напитков при приеме миртазапина.\u003Cbr\u003EПри применении миртазапина в дозе 30 мг один раз в сутки вызывал небольшое, но статистически достоверное повышение международного нормализованного отношения (МНО) у пациентов, получавших лечение варфарином. Нельзя исключать более выраженный эффект при более высокой дозе миртазапина. Рекомендуется контролировать МНО в случае лечения варфарином в сочетании с миртазапином.\u003Cbr\u003EПри одновременном применении миртазапина с другими лекарственными препаратами, которые могут вызывать удлинение интервала QTc (например, некоторые антипсихотические препараты или антибиотики), а также при передозировке миртазапином повышается риск удлинения интервала QT на ЭКГ и/или возникновения желудочковых аритмий (например, тахикардии по типу \"пируэт\").\u003Cbr\u003EФармакокинетическое взаимодействие\u003Cbr\u003EКарбамазепин и фенитоин (индукторы изофермента CYP3A4) увеличивали клиренс миртазапина приблизительно в два раза, что приводило к снижению концентраций миртазапина в плазме крови на 60% и 45% соответственно.\u003Cbr\u003EПри добавлении карбамазепина или другого индуктора печеночного метаболизма (например, рифампицина) к терапии миртазапином дозу миртазапина при необходимости следует увеличить. При прекращении приема индукторов печеночного метаболизма может возникнуть необходимость снижения дозы миртазапина.\u003Cbr\u003EПрименение в сочетании с мощным ингибитором изофермента CYP3A4 кетоконазолом приводило к повышению максимальной концентрации в плазме крови и AUC (площадь под кривой \"концентрация - время\") миртазапина приблизительно на 40% и 50% соответственно.\u003Cbr\u003EПри применении миртазапина в сочетании с циметидином (слабым ингибитором изоферментов CYP1A2, CYP2D6 и CYP3A4) средняя концентрация миртазапина в плазме крови увеличивается более чем на 50%. Следует проявлять осторожность при применении миртазапина в сочетании с мощными ингибиторами изофермента CYP3A4, ингибиторами протеазы ВИЧ, азольными противогрибковыми лекарственными препаратами, эритромицином или нефазодоном. При необходимости дозу миртазапина следует уменьшить.\u003Cbr\u003EВ исследованиях по изучению взаимодействий миртазапин не оказывал влияния на фармакокинетику рисперидона, пароксетина, амитриптилина или препаратов лития."},{"description":"","filters":[{"id":16435314,"name":"Регистрационный номер"}],"isMainProperty":false,"name":"Регистрационный номер","value":"ЛП-001110"},{"description":"","filters":[{"id":16435315,"name":"Дата государственной регистрации"}],"isMainProperty":false,"name":"Дата государственной регистрации","value":"08.02.2017"},{"description":"","filters":[{"id":34324371,"name":"Тип препарата"},{"id":7893318,"name":"Производитель"}],"isMainProperty":false,"name":"Владелец регистрационного 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профилактика)\u003Cbr\u003Eпанические расстройства с агорафобией и без агорафобии\u003Cbr\u003Eобсессивно- компульсивное расстройство (ОКР)\u003Cbr\u003Eпосттравматические стрессовые расстройства (ПТСР)."},{"description":"","filters":[{"id":15768002,"name":"Противопоказания"}],"isMainProperty":false,"name":"Противопоказания","value":"Повышенная чувствительность к активному веществу или другим ингредиентам, входящим в состав препарата\u003Cbr\u003Ecовместное применение сертралина и ингибиторов МАО\u003Cbr\u003Eсовместное применение сертралина с триптофаном или фенилфлурамином\u003Cbr\u003Eсовместное применение с пимозидом\u003Cbr\u003Eэпилепсия в период обострения\u003Cbr\u003Eдетский возраст до 6 лет\u003Cbr\u003Eбеременность и период лактации."},{"description":"","filters":[{"id":15768292,"name":"Состав"}],"isMainProperty":false,"name":"Состав","value":"Действующее вещество: сертралина гидрохлорид, эквивалентный сертралину 55,96 мг или 111,92 мг (50,00 мг или 100,00 мг)\u003Cbr\u003EВспомогательные вещества: кальция гидрофосфат - 16,00 мг или 32,00 мг, целлюлоза микрокристаллическая (Авицель РН 101) - 51,54 мг или 103,08 мг, целлюлоза микрокристаллическая (Авицель РН 102) - 15,00 мг или 30,00 мг, гипроллоза - L - 4,00 мг или 8,00 мг, карбоксиметилкрахмал натрия - 6,00 мг или 12,00 мг, вода очищенная - q.s. (расходуется в процессе производства), магния стеарат - 1,50 мг или 3,00 мг.\u003Cbr\u003EОболочка таблетки:\u003Cbr\u003EОпадрай белый 0Y-S-58910 - 6,00 мг или 12,00 мг (гипромеллоза - 65,00%, титана диоксид - 20,00%, макрогол 400 - 10,00%, тальк - 5,00%), вода очищенная - q.s. (расходуется в процессе производства)."},{"description":"","filters":[{"id":27144131,"name":"Действующее вещество"}],"isMainProperty":false,"name":"Действующее вещество","value":"Сертралин"},{"description":"","filters":[{"id":15768000,"name":"Способ применения и дозы"}],"isMainProperty":false,"name":"Способ применения и дозы","value":"Депрессии и ОКР:\u003Cbr\u003EВзрослые\u003Cbr\u003EВнутрь. 50 мг 1 раз в сутки утром или вечером, независимо от приема пищи. При отсутствии эффекта возможно постепенное (в течение нескольких недель) увеличение дозы до 200 мг/сут (на 50 мг в неделю). Некоторые клиницисты рекомендуют назначать вначале дозу 25 мг/сут в течение 1-2 дней.\u003Cbr\u003EУ пациентов с ОКР для достижения хорошего результата может потребоваться 8-12 недель терапии.\u003Cbr\u003EПанические расстройства и ПТСР: начальная доза - 25 мг/сут утром или вечером с последующим увеличением в течение 1 недели до 50 мг/сут, а затем постепенно на 50 мг в неделю можно увеличить дозу до 200 мг/сут. Терапевтический эффект достигается обычно через 7 дней от начала лечения. Однако, для достижения полного терапевтического эффекта требуется регулярный прием препарата в течение 2-4 недель.\u003Cbr\u003EПри проведении длительной поддерживающей терапии назначают в минимальной эффективной дозе, которую в последующем меняют в зависимости от эффекта.\u003Cbr\u003EУ пожилых пациентов не возникает необходимости в специальном подборе дозы.\u003Cbr\u003EБольные с нарушением функции печени требуют особого внимания при лечении Серлифтом. При тяжелом нарушении функции печени дозу препарата следует уменьшить или же увеличить интервалы между приемами. У больных с нарушением функции почек специально подбирать дозу не требуется.\u003Cbr\u003EДети с ОКР\u003Cbr\u003EДля детей от 6 до 12 лет начальная доза составляет 25 мг сертралина один раз в день, утром или вечером. Через неделю дозу можно увеличить до 50 мг один раз в день.\u003Cbr\u003EУ подростков 13-17 лет начальная доза - 50 мг/сут утром или вечером однократно. Суточную дозу можно постепенно увеличить на 50 мг в неделю до максимальной дозы 200 мг/сут. Следует учитывать меньшую массу тела у детей по сравнению с взрослыми и при назначении дозы более 50 мг/сут необходимо тщательно наблюдать за детьми, чтобы при первых признаках передозировки отменить препарат.\u003Cbr\u003EДля достижения хорошего результата может потребоваться 8-12 недель терапии."},{"description":"","filters":[{"id":15767998,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Со стороны сердечно-сосудистой системы: постуральная гипотензия, тахикардия, гиперемия кожи или \"приливы\" крови к лицу.\u003Cbr\u003EСо стороны органов чувств: нарушение зрения\u003Cbr\u003EСо стороны желудочно-кишечного тракта: редко - анорексия, повышение аппетита\u003Cbr\u003E(возможно как следствие устранения депрессии), сухость во рту, тошнота, рвота, диарея, спазмы в желудке или животе, метеоризм или боли.\u003Cbr\u003EСо стороны нервной системы: головная боль, головокружение, бессонница, сонливость, тремор, нарушения движения (экстрапирамидные симптомы, изменение походки), акатизия, судороги, парестезии, гипестезия, амнезия, симптомы депрессии, галлюцинации, агрессивность, тревога, психомоторное возбуждение, психоз, деперсонализация, нервозность, гипомания, мания, панические реакции, зевота, серотониновый синдром (см. в разделе \"Передозировка\").\u003Cbr\u003EСо стороны опорно-двигательной системы, артралгия, миалгия\u003Cbr\u003EСо стороны гепато-билиарной системы: редко- панкреатит, гепатит, желтуха, печеночная недостаточность, асимптоматическое повышение активности \"печеночных\" трансаминаз (аспартатаминотрансферазы и аланинаминотрансферазы).\u003Cbr\u003EСо стороны мочевыделительной системы, задержка мочи и недержание мочи.\u003Cbr\u003EСо стороны половой системы: нарушение половой функции (задержка эякуляции, снижение потенции и/или либидо, аноргазмия), дисменорея, галакторея.\u003Cbr\u003EСо стороны кожного покрова', сыпь (редко - мультиформная экссудативная эритема, фотосенсибилизация), ангионевротический отек, экхимозы, зуд и анафилактоидные реакции.\u003Cbr\u003EСо стороны обмена веществ и эндокринной системы', гипонатриемия (синдром неадекватной секреции антидиуретического гормона (АДГ), гиперпролактинемия.\u003Cbr\u003EСо стороны системы кроветворения: тромбоцитопения, кровотечения (в т.ч носовое), пурпура. Другие: редко - синдром \"отмены\", повышенное потоотделение; недомогание."},{"description":"","filters":[{"id":15768001,"name":"Фармакологическое действие"}],"isMainProperty":false,"name":"Фармакологическое действие","value":"Антидепрессант, производное нафтиламина. Селективный блокатор обратного нейронального захвата серотонина в головном мозге. На нейрональный захват норадреналина и допамина практически не влияет. Не обладает специфическим сродством к адрено- и м-холинорецепторам, GABA-рецепторам, допаминовым, гистаминовым, серотониновым или бензодиазепиновым рецепторам. Не ингибирует МАО. Вызывает анорексию, эффективен при навязчивых состояниях."},{"description":"","filters":[{"id":34045110,"name":"Фармакологическая группа"}],"isMainProperty":false,"name":"Фармакологическая группа","value":"антидепрессанты"},{"description":"","filters":[{"id":27141511,"name":"Форма выпуска для карточки"}],"isMainProperty":false,"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"description":"","filters":[{"id":35947170,"name":"Способ применения/введения"}],"isMainProperty":false,"name":"Способ применения/введения","value":"пероральный"},{"description":"","filters":[{"id":23679511,"name":"Минимальный возраст применения"},{"id":16082123,"name":"С рождения"}],"isMainProperty":false,"name":"Минимальный возраст применения","value":"от 6 лет"}]},{"name":"Дополнительно","specs":[{"description":"","filters":[{"id":15767999,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"Хранить в сухом месте, недоступном для детей, при температуре не более 25 °С."},{"description":"","filters":[{"id":15768014,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"Тяжелых симптомов при передозировке сертралина не выявлено даже при назначении препарата в больших дозах. Однако, при одновременном применении с другими препаратами или этанолом может возникнуть тяжелое отравление.\u003Cbr\u003EПередозировка может вызвать серотониновый синдром.\u003Cbr\u003EНачальные проявления серотонинового синдрома наблюдаются со стороны нервной системы (экстрапирамидные симптомы - тремор, дезориентация, неусидчивость, мышечный гипертонус; гиперрефлексия; миоклонические подергивания сначала в стопах, затем распространяются по всему телу; атаксия; нарушение координационных проб) и со стороны желудочно-кишечного тракта (спазмы в животе, метеоризм, диарея, тошнота, рвота, диспепсия).\u003Cbr\u003EПри утяжелении состояния развивается маниакальноподобное состояние.\u003Cbr\u003EФинальная стадия напоминает злокачественный нейролептический синдром: лихорадка, профузный пот, маскообразное лицо, сальность лица.\u003Cbr\u003EЛечение: специфических антидотов нет. Требуется интенсивная поддерживающая терапия и постоянное наблюдение за жизненно важными функциями организма. Вызывать рвоту не рекомендуется. Введение активированного угля может быть более эффективным, чем промывание желудка. Необходимо поддерживать проходимость дыхательных путей. У сертралина большой объем распределения, в связи с этим усиление диуреза, проведение диализа, гемолерфузии или переливание крови могут оказаться безрезультатными."},{"description":"","filters":[{"id":15768015,"name":"Применение при беременности и кормлении грудью"}],"isMainProperty":false,"name":"Применение при беременности и кормлении грудью","value":"Беременность и лактация:\u003Cbr\u003EКонтролируемые испытания сертралина у беременных женщин не проводились, в связи с этим во время беременности препарат может быть назначен только в том случае, когда предполагаемая польза для матери превышает возможный риск для плода.\u003Cbr\u003EЖенщины детородного возраста, получающие лечение Серлифтом, должны применять адекватные методы контрацепции. Сертралин обнаруживается в грудном молоке, поэтому применение Серлифта у кормящих женщин не рекомендуется. Если же лечение необходимо, то кормление грудью лучше прекратить."},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"Назначение Серлифта может сопровождаться нарушением психомоторных функций. Поэтому во время лечения Серлифтом необходимо соблюдать осторожность при управлении автотранспортом и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"description":"","filters":[{"id":15771167,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"Серлифт не следует назначать совместно с ИМАО, а также в течение 14 дней после прекращение лечения ИМАО. Аналогично после отмены Серлифта в течение 14 дней не назначают ИМАО.\u003Cbr\u003EУ больных, подвергающихся электросудорожной терапии, достаточный опыт применения сертралина отсутствует.\u003Cbr\u003EНеобходимо осуществлять строгий контроль за поведением больных в состоянии депрессии (риск суицидальных попыток) до тех пор, пока не наступит значительное улучшение в результате проводимого лечения.\u003Cbr\u003EС осторожностью: органические заболевания головного мозга (в т.ч. задержка умственного развития), маниакальные состояния, эпилепсия (в анамнезе и вне обострения), печеночная и/или почечная недостаточность, снижение массы тела, у детей старше 6 лет."},{"description":"","filters":[{"id":15768012,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"Ингибиторы моноаминоксидазы (ИМАО). Отмечаются тяжелые осложнения при одновременном применении сертралина и ИМАО, включая избирательно действующие (селегилин) ИМАО и с обратимым типом действия (моклобемид). Возможно развитие серотонинового синдрома (см. раздел \"Передозировка\").\u003Cbr\u003EЛекарственные средства, угнетающие центральную нервную систему и этанол. Комбинированное применение сертралина и веществ, угнетающих центральную нервную систему, требует наблюдения. Не совместим с этанолом.\u003Cbr\u003EПроизводные кумарина: при их совместном назначении с сертралином отмечается значительное увеличение протромбинового времени - в этих случаях рекомендуется контролировать протромбиновое время в начале лечения Серлифтом и после его отмены.\u003Cbr\u003EЦиметидин. При одновременном применении в значительной степени снижает клиренс сертралина.\u003Cbr\u003EЛекарственные средства, метаболизируемые изоэнзимом 2D6 цитохрома Р450. 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